We team-up with you to facilitate and speed-up your R&D processes
Our Role
Link two essential steps and ensure excellence through your whole drug discovery process. During the pre-clinical drug development phases, you need to focus on the essentials: the discovery. For this, protein sequence design and candidates’ protein screening are keys to your success and probably the main occupations of your teams. However, there is another, paramount step in between: protein expression. And you don’t need to bother with this, this is our expertise and we do it for you:
Being in CHO or in HEK-293 cells, we can either use our own – proprietary – cell lines or, if you choose differently, use a cell line of your choice. We can proceed to codon optimization for you, use either your vector or our vector. Our expertise is in Transient Protein Expression. Then, our know-how and our protein expression media will make the difference. Our promise is that you will get, in as low as 14 days after we receive your sequences, your expressed proteins in a cell-free supernatant with a satisfactory titer:
Depending on the protein we can reach titers as high as 1g/L in TGE
Even with difficult to express proteins we generally reach at least 100 mg/L in TGE
In particularly difficult cases we can optimize our production processes to reach your objectives
And a high quality / high level of purity.
How Does It Work?
1.
We discuss about your needs, advise you on various possible options and define, in a work order, all the elements of our collaboration
2.
We receive your DNA constructs, and we immediately initiate the expression process according to the agreed specifications
3.
We measure the Key Performance Indicators (KPIs) according to the agreed plan (i.e. cell transfection rate, viability, titer)
4.
We send you the cell-free supernatants (agreed volume) for each construct and a production report with all the measured KPI
5.
We debrief with you on the results and provide you with any needed additional support
1.
We discuss about your needs, advise you on various possible options and define, in a work order, all the elements of our collaboration
2.
We receive your DNA constructs, and we immediately initiate the expression process according to the agreed specifications
3.
We measure the Key Performance Indicators (KPIs) according to the agreed plan (i.e. cell transfection rate, viability, titer)
4.
We send you the cell-free supernatants (agreed volume) for each construct and a production report with all the measured KPI
5.
We debrief with you on the results and provide you with any needed additional support
Your Advantages In Partnering With Us
We Work With You as a Team
your objectives are our objectives, and we find the solutions to reach them.
Reliable Protocols
Our cell lines either in CHO or in HEK, our expression system and our protocols are extremely robust and reliable: they are the fruit of over 40 years’ experience by our Founders.
High Flexibility
We are highly flexible and adapt to your needs: we optimize what needs to be optimized considering your context and any of your special requirements.
Precision
We are fast and precise: our commitment is for you to get what you need when you need.
High Purity
We are specialized in, and we only do Protein Expression: we aim at high yield, even for difficult to express protein, and high purity.
Laboratory Biocant Park -Parque Tecnológico de Cantanhede Edifício III – Laboratório 5 3060-197 Cantanhede, Portugal
+351 911 004 699 +351 231 249 290
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